Differences

This shows you the differences between two versions of the page.

--- ms [2025/10/14 04:55] – [Conclusion] miko
+++ ms [2025/11/25 16:37] (current) – external edit 127.0.0.1
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-====== Ocrevus (ocrelizumab) – Preparation Guide ======
+====== Ocrevus (ocrelizumab) – Medication Overview ======
-Ocrevus is a monoclonal antibody used to treat multiple sclerosis (MS). Before starting treatment, several medical and logistical preparations are required to ensure safety and effectiveness.
+Ocrevus is a prescription medicine used to treat certain forms of multiple sclerosis (MS). It is a humanized monoclonal antibody that targets CD20-positive B cells, which are believed to play a role in the disease process.
-===== 🧪 Medical Preparations =====
+===== 🧬 Mechanism of Action =====
-  * **Hepatitis B screening**: Test for HBsAg and anti-HBc. Active infection is a contraindication.
+Ocrevus binds to the CD20 protein found on the surface of B cells. By depleting these cells, it helps reduce inflammation and slow the progression of MS.
-  * **Vaccination check**: Live vaccines should be given at least 6 weeks before starting treatment.
-  * **Blood tests**: Check white blood cells, lymphocytes, and immunoglobulin levels (especially IgG).
-  * **Infection status**: Postpone infusion if any active infection is present.
-===== 💊 Pre-medication =====
+===== 🎯 Approved Indications =====
-To reduce the risk of infusion reactions, the following are typically administered 30–60 minutes before infusion:
+  * **Relapsing-remitting MS (RRMS)** – Reduces the frequency of relapses and MRI activity.
-  * **Corticosteroid** (e.g. 100 mg IV methylprednisolone)
+  * **Primary progressive MS (PPMS)** – Slows disability progression; first approved treatment for this form.
-  * **Antihistamine** (e.g. diphenhydramine or cetirizine)
-  * **Paracetamol (acetaminophen)**
-===== 🏥 Infusion Logistics =====
+===== 💉 Administration =====
-  * **First dose**: Two 300 mg infusions, spaced two weeks apart.
+  * Given as an **intravenous infusion** every 6 months.
-  * **Subsequent doses**: 600 mg every 6 months.
+  * The first dose is split into two infusions (Day 1 and Day 15).
-  * **Observation**: Minimum 1 hour monitoring after each infusion.
+  * Subsequent doses are single infusions every 24 weeks.
-  * **Support**: Consider bringing someone with you for the first infusion.
-===== 📋 Additional Recommendations =====
+===== ⚠️ Common Side Effects =====
-  * **Contraception**: Use effective birth control during treatment and for 6 months after the last dose.
+  * Infusion-related reactions (fever, rash, throat irritation)
-  * **Breastfeeding**: Not recommended during treatment and for 6 months after the last infusion.
+  * Increased risk of infections (e.g. respiratory, herpes)
-  * **COVID-19 vaccination**: Ideally completed before starting Ocrevus, as immune response may be reduced.
+  * Possible reduction in immunoglobulin levels over time
-===== 📝 Notes =====
+===== 📋 Monitoring and Safety =====
-Always consult your neurologist or MS specialist before starting Ocrevus. This guide is for informational purposes and does not replace medical advice.
+  * **Hepatitis B screening** required before starting treatment.
+  * **Vaccinations** should be updated prior to therapy; live vaccines are not recommended during treatment.
+  * Regular **blood tests** and clinical monitoring are advised.
+===== 🧾 Additional Notes =====
+  * Not recommended during pregnancy or breastfeeding.
+  * Effective contraception is advised during treatment and for 6 months after the last dose.
+  * Patients should remain under the care of a neurologist or MS specialist.
+===== 🔗 References =====
+This summary is based on publicly available medical guidelines and product information. Always consult your healthcare provider for personalized advice.